Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We examined the association of circulating levels of IGF-1, IGFBP-3 and IGFBP-1, and SNPs in the IGF-1 receptor (IGF1R), IGF-2 receptor (IGF2R), and insulin receptor genes with risk of adenomas in a sample of 410 incident adenoma cases and 1,070 controls from the Case Transdisciplinary Research on Energetics and Cancer (TREC) Colon Adenomas Study.
|
24194259 |
2014 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We considered patients as "poorly controlled" who still showed elevated GH and IGF-I plasma levels, uninhibited GH after OGTT (GH > 1 microg/l), presence of clinical activity and/or radiological signs of adenoma recurrence, even if a reduction of tumor size had been demonstrated.
|
11972303 |
2002 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Univariate analyses confirmed that sGHD recovery improved significantly in patients that were younger, had only undergone a single primary surgery, had not had anterior hormone deficiency except GH, and had cystic adenoma or normal insulin-like growth factor-1 (IGF1) standard deviation score (SD-S) levels immediately after surgery.
|
29910227 |
2018 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings suggest that the attenuation of negative feedback through the pituitary GH-IGF-I axis may be involved in development of GH-producing adenoma.
|
10498342 |
1999 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The preoperative free thyroxine, thyroxine, GH, IGF-1, follicular-stimulating hormone, and luteinizing hormone levels were significantly lower in the giant adenoma group (n = 43) than in the large adenoma group (n = 121).
|
30880207 |
2019 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The E-cadherin level correlated positively to tumor reduction after SMS treatment, and adenomas with nuclear E-cadherin staining had lower IGF-I reduction and tumor shrinkage.
|
20335450 |
2010 |
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Somatostatin and lanreotide inhibited cell proliferation in phorbol ester (PMA)-stimulated conditions (10/13 adenomas), as well as after fetal calf serum (3/3 adenomas) or IGF-I stimulation (2/2 adenomas).
|
12807513 |
2003 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Recent data suggest that soluble Klotho (sKlotho), besides and in addition to IGF-1, may help monitor the activity of GH-producing adenomas (presumably reflecting GH action on the kidneys) and may be a useful supplementary tool.
|
23648743 |
2013 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Males showed plurihormonal focal pituitary transgene expression with LH-, TSH-, and, unexpectedly, also GH-cell focal hyperplasia and adenoma, associated with increased serum LH, GH, testosterone, and/or IGF-I levels.
|
15677710 |
2005 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Larger initial adenoma size (odds ratio [OR] 12.0, 95% confidence interval [CI] 1.02-141.3; p = 0.048) and high post-operative IGF-1 levels (OR 4.5, 95% CI 1.1-19.2; p = 0.040) were predictors for non-full remission and uncontrolled disease, respectively.
|
30141524 |
2018 |
Adenoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Hepatobiliary and gastrointestinal manifestations of acromegaly.
|
1611713 |
1992 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Cryosectioned normal human adrenal glands (n = 6), cortical adenoma (n = 21), and carcinoma (n = 17) were stained immunohistochemically for IGF-1 and its receptor, and human adrenocortical cancer cells expressing the receptor were analysed for influences on proliferation.
|
8669808 |
1996 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A corresponding up-regulation of IGF-1 mRNA was documented in carcinomas, whereas adenomas exhibited down-regulated expression of IGF-1 mRNA.
|
10937058 |
2000 |
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
IGF-1 was found to have a significant and negative correlation with adenoma median long- and short-axis length.
|
29975581 |
2018 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
IGF-1 levels may increase to clinically significant levels during cabergoline treatment for PRL-adenoma.
|
29728863 |
2018 |
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
IGF-IR expression was significantly higher in pediatric adrenocortical carcinomas than adenomas (9.1 +/- 3.1 vs. 2.6 +/- 0.3; P = 0.0001), whereas its expression was similar in adult adrenocortical carcinomas and adenomas.
|
18611974 |
2008 |